Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.
Mitotane, C14H10Cl4
Schematic representation of mitotane metabolism [59, 60, 65-67].
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Effects of adrenolytic mitotane on drug elimination pathways assessed in vitro
Major apoptotic pathways (redrawn from Bali et al., (59), with
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The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
PPT - Antineoplastic Agents: Part II PowerPoint Presentation, free download - ID:4737249
The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells
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Frontiers Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
Chemical Name : Mitotane-d4